|
|
|
|
|
| Brilhante,Raimunda Sâmia Nogueira; Caetano,Érica Pacheco; Riello,Giovanna Barbosa; Guedes,Glaucia Morgana de Melo; Castelo-Branco,Débora de Souza Collares Maia; Fechine,Maria Auxiliadora Bezerra; Oliveira,Jonathas Sales de; Camargo,Zoilo Pires de; Mesquita,Jacó Ricarte Lima de; Monteiro,André Jalles; Cordeiro,Rossana de Aguiar; Rocha,Marcos Fábio Gadelha; Sidrim,José Júlio Costa. |
| Abstract Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1 μg mL−1 for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4 μg mL−1and from 0.0625 to 1 μg mL−1 for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Histoplasma capsulatum; Saquinavir; Ritonavir; Itraconazole. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200155 |
| |
|
|
| Brito,Erika Helena Salles de; Fontenelle,Raquel Oliveira dos Santos; Brilhante,Raimunda Sâmia Nogueira; Cordeiro,Rossana de Aguiar; Sidrim,José Júlio Costa; Rocha,Marcos Fábio Gadelha. |
| O gênero Candida é composto por leveduras que vivem como comensais na microbiota de homens e animais. Em geral, não causam nenhum dano aos seus hospedeiros, entretanto, em virtude de desequilíbrios nas defesas química, física e imunológica, esses microrganismos podem se tornar patogênicos. Infecções por Candida spp. são pouco frequentes na Medicina Veterinária no entanto, nos últimos anos, tem sido observado aumento considerável de relatos de enfermidades causadas por essas leveduras, acometendo diferentes animais. Várias espécies do gênero são implicadas em quadros infecciosos, sendo a C. albicans a principal delas, seguida por C. tropicalis e C. parapsilosis. Considerando-se o potencial patogênico do gênero Candida, aliado ao surgimento de cepas... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida; Candidose; Veterinária; Derivados azólicos e resistência. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000900046 |
| |
|
|
| Rocha,Marcos Fábio Gadelha; Aguiar,Franscisco Léo Nascimento de; Brilhante,Raimunda Sâmia Nogueira; Cordeiro,Rossana de Aguiar; Teixeira,Carlos Eduardo Cordeiro; Castelo-Branco,Débora de Souza Collares Maia; Paiva,Manoel de Araújo Neto; Zeferino,João Paulo Otaviano; Mafezoli,Jair; Sampaio,Célia Maria de Souza; Barbosa,Francisco Geraldo; Sidrim,José Júlio Costa. |
| O aumento da incidência das infecções fúngicas, bem como o registro crescente de resistência e falha terapêutica, têm impulsionado a realização de estudos de prospecção de fitoquímicos com propriedades antifúngicas. Diante do exposto, o presente estudo investigou o potencial antifúngico de extratos de Baccharis ligustrina, B. schultzii, Croton jacobinensis, Licania rigida, Moringa oleifera, Vernonia sp. e V. brasiliana, e de óleos essenciais de Lippia alba (Quimiotipos 1, 2, 3 e 4) e Ocimum gratissimum. Inicialmente, foi realizada uma avaliação qualitativa da atividade antifúngica de cada amostra por meio do método de difusão em ágar, frente a cepas de Candida albicans e Microsporum canis, mostrando que apenas os extratos de M. oleifera (MLF-C) e Vernonia... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Atividade antifúngica extratos vegetais Moringa oleifera; Vernonia sp. Candida albicans Microsporum canis. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782011001000022 |
| |
|
|
| Brilhante,Raimunda Sâmia Nogueira; Paiva,Manoel de Araújo Neto; Sampaio,Célia Maria de Souza; Teixeira,Carlos Eduardo Cordeiro; Ribeiro,Joyce Fonteles; Castelo-Branco,Débora de Souza Collares Maia; Bandeira,Tereza de Jesus Pinheiro Gomes; Monteiro,André Jalles; Cordeiro,Rossana de Aguiar; Sidrim,José Júlio Costa; Monteiro,Frederico Ozanan Barros; Moreira,José Luciano Bezerra; Rocha,Marcos Fábio Gadelha. |
| This study aimed to evaluate the role of the Amazon River prawn, Macrobrachium amazonicum, as carrier of Candida spp., by analyzing the correlation between Candida spp. from these prawns and their environment (surface water and sediment), through M13-PCR fingerprinting and RAPD-PCR. For this purpose, 27 strains of Candida spp. were evaluated. These strains were recovered from the gastrointestinal tract of adult M. amazonicum (7/27) from Catú Lake, Ceará State, Brazil and from the aquatic environment (surface water and sediment) of this lake (20/27). Molecular comparison between the strains from prawns and the aquatic environment was conducted by M13-PCR fingerprinting and RAPD-PCR, utilizing the primers M13 and OPQ16, respectively. The molecular analysis... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Macrobrachium amazonicum prawn environmental sentinel Candida spp. pollution; Monitoring. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014001102029 |
| |
|
|
| Rocha,Marcos Fábio Gadelha; Alencar,Lucas Pereira de; Brilhante,Raimunda Sâmia Nogueira; Sales,Jamille de Alencar; Ponte,Yago Brito de; Rodrigues,Pedro Henrique de Aragão; Sampaio,Célia Maria de Souza; Cordeiro,Rossana de Aguiar; Castelo-Branco,Débora de Souza Collares Maia; Oliveira,Francisco Carlos de; Barbosa,Francisco Geraldo; Teixeira,Carlos Eduardo Cordeiro; Paiva,Manoel de Araújo Neto; Bandeira,Tereza de Jesus Pinheiro Gomes; Moreira,José Luciano Bezerra; Sidrim,José Júlio Costa. |
| This study aimed to evaluate the antifungal activity of M. oleifera extracts against fungi isolated from farmed prawns and test the toxicity of the extracts on larvae of Macrobrachium amazonicum. The ethanol extracts of pods, seeds, leaves, stems and flowers and chloroform extract of flowers of M. oleifera were tested against 14 strains of Candida spp. and 10 strains of Hortaea werneckii isolated from farming water and the digestive tract of M. amazonicum. Antifungal activity was determined by microdilution, based on the M27-A3 and M38-A2 CLSI documents. Toxicity was evaluated by exposing larvae of M. amazonicum at concentrations between 10-1000mg mL-1, counting dead larvae (CL50) after 24 hours. The best results were verified with the chloroform extract... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aquaculture; Fungi; Prawn; Moringa oleifera; Antimicrobial. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014001202197 |
| |
|
|
| Brilhante,Raimunda Sâmia Nogueira; Caetano,Erica Pacheco; Oliveira,Jonathas Sales de; Castelo-Branco,Débora de Souza Collares Maia; Souza,Elizabeth Ribeiro Yokobatake; Alencar,Lucas Pereira de; Cordeiro,Rossana de Aguiar; Bandeira,Tereza de Jesus Pinheiro Gomes; Sidrim,José Júlio Costa; Rocha,Marcos Fábio Gadelha. |
| ABSTRACTThe antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested againstCandida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug was evaluated in combination with antifungal drugs against planktonic growth and tested against biofilms ofCandida spp. and Cryptococcus spp. Drug susceptibility testing was performed using the microdilution broth method, as described by the Clinical and Laboratory Standards Institute. The interaction between simvastatin and antifungals against planktonic cells was analyzed by calculating the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida; Cryptococcus; Simvastatin; Antifungal activity; Biofilm. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500459 |
| |
|
|
| Meireles,Tereza Elizabeth Fernandes; Rocha,Marcos Fábio Gadelha; Brilhante,Raimunda Sâmia Nogueira; Cordeiro,Rossana de Aguiar; Sidrim,José Júlio Costa. |
| Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts and moulds, accounting for about 50% of onychopathies. A high frequency of onychomycosis caused by Candida species has been reported during the last few years in northeast Brazil, as well as in other regions of the world. A clinical diagnosis of onychomycosis needs to be confirmed through laboratory exams. We evaluated the importance of serial repetition of direct microscopic exams and fungal culture for the diagnosis of onychomycosis in the city of Fortaleza, Ceará, in northeast Brazil. We first made a retrospective study of 127 patients with onychomycosis, identifying the fungi that had been isolated from fingernails and toenails. We then made a prospective study of 120... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diagnosis; Onychomycosis; Candida; Moulds and dermatophytes. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400016 |
| |
|
|
| Brilhante,Raimunda Sâmia Nogueira; Caetano,Érica Pacheco; Lima,Rita Amanda Chaves de; Marques,Francisca Jakelyne de Farias; Castelo-Branco,Débora de Souza Collares Maia; Melo,Charlline Vládia Silva de; Guedes,Glaucia Morgana de Melo; Oliveira,Jonathas Sales de; Camargo,Zoilo Pires de; Moreira,José Luciano Bezerra; Monteiro,André Jalles; Bandeira,Tereza de Jesus Pinheiro Gomes; Cordeiro,Rossana de Aguiar; Rocha,Marcos Fábio Gadelha; Sidrim,José Júlio Costa. |
| Abstract This study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and β-lapachone against strains of Coccidioides posadasii in filamentous phase (n = 22) and Histoplasma capsulatum in both filamentous (n = 40) and yeast phases (n = 13), using the broth dilution methods as described by the Clinical and Laboratory Standards Institute, to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of these compounds. The mechanisms of action of these compounds were also investigated by analyzing their effect on cell membrane permeability and ergosterol synthesis. The MIC and MFCf these compounds against C. posadasii, mycelial H. capsulatum, and yeast-like H. capsulatum, were in the following... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dimorphic fungi; Terpinen-4-ol; Tyrosol; Β-Lapachone; Inhibitory effect. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400917 |
| |
|
|
|
